Listing a study does not mean it has been evaluated by the u. Amantadine symmetrel side effects, dosage, interactions. Amantadine is a synthetic manmade antiviral drug that can inhibit the replication of viruses in cells. This medication works best when the amount of medicine in your body is kept at a constant. This document is considered to be a guide only and is not intended to replace sound clinical practice. Symmetrel amantadine hydrochloride, usp is designated generically as amantadine hydrochloride and chemically as 1adamantanamine hydrochloride. This makes the pdf file part of the presentation file.
Amantadine infusion in treatment of motor fluctuations and dyskinesias in parkinsons disease article pdf available in journal of neural transmission 10711. Amantadine comes as a capsule, extendedrelease capsule gocovri, tablet, and liquid to take by mouth. The 4 approved therapeutic medications amantadine hydrochloride, rimantadine hydrochloride, zanamivir, and oseltamivir must be started within 30 to 48 hours of initial symptoms for any appreciable benefit to the patient, yet only a small fraction of patients present to their primary care providers within this time frame. Oral dosage immediaterelease capsules, oral solution, or tablets. Amantadine is used to treat a group of side effects called parkinsonian side effects that include tremors, difficulty walking, and slack. Safety and efficacy of ads5102 amantadine extended release. The dosage of amantadine was within the standard dose range. Amantadine is used in animals suffering from windup, allodynia, and opioid tolerance. Drugs that may lower seizure threshold epilepsy foundation.
However, slowly administered intravenous physostigmine in 1 and 2 mg doses in an adult2 at 1 to 2hour intervals and 0. Amantadine hydrochloride has pharmacological actions as both an antiparkinson and an antiviral drug. Nov 19, 2019 amantadine hydrochloride usp is designated generically as amantadine hydrochloride and chemically as 1adamantanamine hydrochloride. The administration of amantadine tablets as a 200 mg single dose to 6 healthy subjects resulted in a cmax of 0. By continuing to browse this site you are agreeing to our use of cookies. Find out what health conditions may be a health risk when taken with amantadine hcl oral. Amantadine hydrochloride monograph for professionals. Has been used for treatment of uncomplicated respiratory tract illness caused by susceptible influenza a virus in adults, adolescents, and children. Shingrix is a vaccine indicated for prevention of herpes zoster shingles in adults aged 50 years and older. Sep 23, 2019 the recommended dosage for patients on hemodialysis is 200 mg every 7 days.
Amantadine for improving neurologic symptoms in ataxia. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication. Amantadine and rimantadine function in a mechanisticallyidentical fashion, entering the barrel of the tetrameric m 2 channel and blocking pore functioni. Amantadine hydrochloride oral solution, usp description. Amantadine and its derivative, rimantadine, can be used successfully in the prevention and treatment of influenza a. Studies in children proved amantadine to be a safe and tolerable drug. Amantadine use may permit a lower dose of the opioid and helps increase analgesia provided by the opioid. Substitutions that confer resistance to rimantadine include most frequently m2 s31n, as well as the less common changes v27a, v30a, l26f and a30t ref. Highlights of prescribing information for osmolex er.
Amantadine oral capsule 100mg drug medication dosage information. Amantadine hydrochloride oral solution usp, 50 mg per 5 ml 1 teaspoonful is supplied as a clear raspberry flavored oral solution supplied in a 16 fl oz 473 ml container, and in 10 ml unit dose cups, packaged in trays of 10. Pdf amantadine infusion in treatment of motor fluctuations. Gocovri amantadine extended release capsules prescribing information. How to use amantadine hcl capsule, extended release 24 hr capsule, er hr take this medication by mouth with or without food as directed by your doctor, usually once daily. Amantadine was administered to 24 healthy children with adhd, aged 5 year old. Thus, the dose of amantadine hydrochloride should be reduced in patients with renal impairment and in individuals who are 65 years of age or older.
Insert pdf file content into a powerpoint presentation. Amantadine hydrochloride drug bnf content published. Amantadine, sold under the brand name gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type a influenzavirus, though its use for the latter is no longer recommended due to drug resistance. Amantadine may not be effective during every flu season because certain strains of the virus may be resistant to this medicine.
Link to the pdf file there and select the pdf file, then ok. Crossresistance among the adamantanes, rimantadine and amantadine, has been observed. Fatigue, a common and disabling symptom experienced by patients with multiple sclerosis ms, may encompass both physical and cognitive characteristics. It is sold in the united states under the brand name symmetrel, and is also available under its generic name purpose. Open powerpoint and display the slide where you want to insert the pdf text. Sep 17, 2014 amantadine is an antiviral agent, specifically active against influenza a viruses. The mechanism of action for treating msassociated fatigue is unclear, but it may be related to antiviral activity, immunemediated activity, or an amphetaminelike action. Amantadine definition amantadine is a synthetic antiviral agent that also has strong antiparkinsonian properties. Amantadine, drug used to treat infections caused by influenza type a virus, the most common cause of influenza epidemics. Each tablet intended for oral administration contains 100 mg amantadine.
It is sold in the united states 1 under the brand name symmetrel, and is also available under its generic name. Amantadine is the generic form of the brandname drug symmetrel, which is used to treat and prevent respiratory infections caused by the influenza a virus it. Amantadine may potentially alter breast milk production or excretion, a factor which should be taken into account when considering the use of amantadine in breastfeeding mothers. The cdc does not recommend treating the flu with amantadine in the u. Amantadine oral solution usp fda prescribing information. Unfortunately, effective rational therapy for msrelated. It was initially used to prevent influenza a during flu season, and, if given within 24 to 48.
Amantadine hydrochloride oral solution contains 50 mg of amantadine hydrochloride per 5 ml and has the following inactive ingredients. Amantadine is an antiviral medication used to treat respiratory track infections. These highlights do not include all the information needed to use. Amantadine hydrochloride capsules drug information. It is used to prevent and to treat a specific type of flu called influenza a. Amantadine and rimantadine for influenza a in adults jefferson, t. If neither of those two methods work for your needs, you can also add a pdf file into a powerpoint presentation as an action. Jan 26, 2017 what is amantadine gocovri, osmolex er, symmetrel. Amantadine is a synthetic antiviral agent that also has strong antiparkinsonian properties. Symmetrel amantadine hydrochloride side effects, images.
This medicine is also used to treat parkinsons disease and other movement disorders. Amantadine hydrochloride 1 is an antiviral drug used in the. Amantadine definition of amantadine by medical dictionary. Amantadine was administered with a dosage of 100 mg daily with no severe side.
It acts as a nicotinic antagonist and noncompetitive nmda antagonist. In another study, after 15 days of amantadine 100 mg b. Amantadine versus ritalin in the treatment of attention. Incidence of adverse reactions from pooled studies of immediaterelease amantadine. The combined use of namenda with other nmda antagonists amantadine, ketamine, and dextromethorphan has not been systematically evaluated and such use should be approached with caution.
Similarly, amantadine coadministration did not affect oseltamivir pk auc012. Amantadine intoxication despite moderate renal dysfunction. Take amantadine at around the same time s every day. Amantadine was first approved by the us food and drug administration fda as a prophylactic agent against asian influenza in 1966 and. Amantadine hydrochloride capsules amantadine hydrochloride. Category drug comment antiasthmatics aminophylline theophylline especially but not exclusively above therapeutic levels antibiotics isoniazid lindane metronidazole nalidixic acid penicillins vitamin b6 supplement may protect especially with renal failure antidepressants tricyclics serotoninspecific agents bupropion rarely a practical problem. The drug package insert should be consulted for dosage recommendations for administering amantadine to persons with creatinine clearance. Amantadine hydrochloride usp is designated generically as amantadine hydrochloride and chemically as 1adamantanamine hydrochloride. Jul 31, 2009 amantadine is a safe drug with mild side effects. Shingrix is not indicated for prevention of primary varicella infection chickenpox. Amantadine is a medicine licensed to treat the flu, parkinsons disease, and side effects from other drugs.
Apr 06, 2010 attentiondeficit hyperactivity disorder adhd is the most common neurobehavioural disorder of childhood. A drug, c10h17, used in its hydrochloride form as an antiviral agent and treatment for parkinsons. Amantadine is an fda approved drug for treatment and prevention of influenza, parkinson disease and drug induced dyskinesia. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for amantadine hydrochloride. In the insert object box, select create from file, and then enter the pdf file location. Across studies, the time to cmax tmax averaged about 2 to 4 hours. Amantadine is also used to treat symptoms of parkinsons disease and to treat the side effects caused by certain psychiatric drugs. A minimum of 1 week of treatment with the previous dose should be observed before increasing the dose. Amantadine is a dopamine agonist and at usual prescribed doses may inhibit lactation.
Amantadine oral capsule 100mg drug medication dosage. This emedtv segment covers amantadine uses in more detail, describes the possible side effects of the drug, and offers some dosing tips. Hcl amantadine hydrochloride usp is a white or practically white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform. Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in. Amantadine is used to treat or prevent influenza a in adults and children. This medication is best taken on an empty stomach, but may be taken with food or milk if stomach upset occurs. Amantadine versus ritalin in the treatment of attention deficit hyperactivity disorder adhd the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Sutiak1 1university of veterinary medicine, kosice, slovak republic 2university of p. Symmetrel is an antiviral drug used to prevent certain types of the flu by stopping the viruss growth, and to treat respiratory symptoms of the flu. Deaths have been reported from overdose with amantadine hydrochloride. The capsules, tablets, and liquid medications are usually taken once or twice a day. Crushing guide for oral medication in residents with. Amantadine hydrochloride drug bnf content published by nice.
An improved synthesis of amantadine hydrochloride organic. It has very little or no activity against influenza b virus isolates. The extendedrelease capsules are taken once a day at bedtime. Open your powerpoint presentation on the page you want to insert the pdf within. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Because amantadine hydrochloride is primarily excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Clearly, this is not practical for most viral infections. For the treatment of druginduced extrapyramidal symptoms eps. Amantadine is the generic form of the brandname drug symmetrel, which is used to treat and prevent respiratory infections caused by the influenza a virus it can also treat symptoms of parkinson. Jan 26, 2017 symmetrel amantadine hydrochloride, usp is designated generically as amantadine hydrochloride and chemically as 1adamantanamine hydrochloride. Neither drug affected the rate of viral shedding from the nose or the course of asymptomatic influenza. It will not work for colds, other types of flu, or other viral infections. The investigators hypothesized that amantadine would be beneficial for treatment of adhd, and this could be evaluated in a double blind, randomized, parallel group comparison of amantadine and ritalin. Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.
Amantadine is an antiviral medicine that blocks the actions of viruses in your body. To prevent a viral infection, the drug should be present before exposure to the virus. Amantadine is an antiviral agent that specifically inhibits influenza a virus replication at a micromolar concentration. Resistance to rimantadine confers crossresistance to amantadine and viceversa. In this study we report a higher geometric mean of c max of 0. A randomized, crossover study to evaluate the pharmacokinetics. Webmd provides common contraindications for amantadine hcl oral. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. How to use amantadine hcl capsule, extended release 24 hr capsule, er hr take this medication by mouth with or without food as directed by. In powerpoint, select the slide that you want to add the file to, and then select insert object. Increase dose in 5 mg increments to a maintenance dose of 10 mg twice daily. The daily dosage should be divided into 2 to 3 daily portions.